EXPERIMENTAL REPLACEMENT OF BONE DEFECTS OF CEREBRAL CRANIUM WITH FINE PROFILE TITANIUM NICKELIDE

Abstract

Purpose. Development of a new medical technology for surgical removal of defects in the bones of the brain skull using materials with shape memory. Method. Experimental replacement of bone structures of the brain skull was performed on 69 mongrel rabbits aged 1–1,5 years. The defects were created artificially by symmetrical excision of bone tissue in the parietal and temporal areas of 15.0×15.0 mm without disturbing the integrity of the Dura mater. To eliminate the obtained defects, a thin-profile superelastic titanium Nickel mesh with a thickness of 40, 60 and 90 µm was used, placed in one, two and four layers. For morphological study the material was collected on day 7, 14, 21, 28 and 35. In each variant, 3 series of experiments were carried out (135 in total, taking into account the multiplicity of the material intake for histological studies). Controls were similarly educated 3 flaw left without replacement. Results. It was found that the optimal structure of the regenerate was obtained as a result of the use of a four-layer mesh structure made of a 40 µm thick thread as an implantation material. In the thickness of the outer layers, organotypic lamellar and spongy bone tissue was obtained, in the thickness of the inner layers – dense semi-formed connective tissue. Formed in these cases, a single regenerate with implantation material makes it possible to fully restore the anatomical and functional features of the bone structures of the brain skull, Dura and brain. The study of the processes of osteogenesis depending on the thickness of the threads from which the implant material was made did not reveal significant differences. The results obtained allow us to recommend the introduction of the developed technology in a wide clinical practice.

Keywords

• никелид титана
• костные дефекты свода черепа
• остеогенез