Pharmacological potential of Curcuma longa endophytes
Garima Sharma,
Surbhi Agarwal,
Rashmi Bhardwaj,
Vitthal T. Barvkar,
Rucha C. Godbole,
Vinay Kumar,
Nandita Narayanasamy,
Vartika Mathur
Affiliations
Garima Sharma
Animal-Plant Interactions Lab, Department of Zoology, Sri Venkateswara College, University of Delhi, New Delhi 110021, India; Centre for Medical Biotechnology, Maharshi Dayanand University, Rohtak, Haryana 124001, India
Surbhi Agarwal
Animal-Plant Interactions Lab, Department of Zoology, Sri Venkateswara College, University of Delhi, New Delhi 110021, India
Rashmi Bhardwaj
Centre for Medical Biotechnology, Maharshi Dayanand University, Rohtak, Haryana 124001, India
Vitthal T. Barvkar
Department of Botany, Savitribai Phule Pune University, Pune 411007, India
Rucha C. Godbole
Department of Botany, Savitribai Phule Pune University, Pune 411007, India
Vinay Kumar
Department of Biotechnology, Modern College of Arts, Science and Commerce, S. P. Pune University, Ganeshkhind, Pune 411016, India
Nandita Narayanasamy
Department of Biochemistry, Sri Venkateswara College, University of Delhi, New Delhi 110021, India
Vartika Mathur
Animal-Plant Interactions Lab, Department of Zoology, Sri Venkateswara College, University of Delhi, New Delhi 110021, India; Fellow of Institute of Eminence, School of Climate Change and Sustainability, University of Delhi, Delhi 110007, India; Correspondence to: Animal-Plant Interactions Lab, Department of Zoology, Sri Venkateswara College University of Delhi, South campus, Benito Juarez Marg, Dhaula Kuan, New Delhi 110021, India
Endophytes contribute to plant fitness and defence by producing bioactive secondary metabolites, which may be utilized in various industrial applications. We assessed the potential of bioactive compounds from the endophytes of Curcuma longa for therapeutic properties. We screened phytochemicals obtained from the C. longa endophytes for host-specific bioactive compounds which were also evaluated for their antimicrobial, anti-inflammatory and antioxidant potential. 59 endophytes were isolated from leaves and rhizome of C. longa, among which isolates Fusarium fujikuroi PCLCUT2 and Bacillus pacificus NCLALC2 showed significant antioxidant and anti-inflammatory properties. PCLCUT2 showed strong antioxidant potential (IC50 1.33 mg/mL) and the presence of compounds such as (-)-epicatechin and curcumin. B. pacificus NCLALC2 exhibited strong anti-inflammatory and antimicrobial potential (MIC 200 µg/L) against Mycobacterium smegmatis. NCLALC2 showed the presence of 12 potential bioactive compounds including Calicoferol D, terpinolene and alpha-phellandrene. With the presence of host-specific compounds, the two endophytes hold promising potential as cost-effective sources of bioactive metabolites for pharmacological applications.
