Nature Communications (May 2017)
Structural basis for conductance through TRIC cation channels
- Min Su,
- Feng Gao,
- Qi Yuan,
- Yang Mao,
- De-lin Li,
- Youzhong Guo,
- Cheng Yang,
- Xiao-hui Wang,
- Renato Bruni,
- Brian Kloss,
- Hong Zhao,
- Yang Zeng,
- Fa-ben Zhang,
- Andrew R Marks,
- Wayne A Hendrickson,
- Yu-hang Chen
Affiliations
- Min Su
- State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
- Feng Gao
- State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
- Qi Yuan
- Department of Physiology and Cellular Biophysics, Columbia University
- Yang Mao
- State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
- De-lin Li
- University of Chinese Academy of Sciences
- Youzhong Guo
- Department of Biochemistry and Molecular Biophysics, Columbia University
- Cheng Yang
- State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University
- Xiao-hui Wang
- University of Chinese Academy of Sciences
- Renato Bruni
- Center on Membrane Protein Production and Analysis, New York Structural Biology Center
- Brian Kloss
- Center on Membrane Protein Production and Analysis, New York Structural Biology Center
- Hong Zhao
- State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
- Yang Zeng
- University of Chinese Academy of Sciences
- Fa-ben Zhang
- University of Chinese Academy of Sciences
- Andrew R Marks
- Department of Physiology and Cellular Biophysics, Columbia University
- Wayne A Hendrickson
- Department of Physiology and Cellular Biophysics, Columbia University
- Yu-hang Chen
- State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/ncomms15103
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Trimeric intracellular cation channels (TRICs) elicit K+ currents to counteract luminal negative potential during Ca2+release from intracellular stores. Here the authors present structures of prokaryotic TRICs in their open and closed states, obtaining molecular insight into TRICs’ function.
