PROSPECTS FOR THE USE OF BIOMARKERS (ADIPONECTIN, P-SELECTIN, INTEGRIN Ββ3) AS BIOCHEMICAL PREDICTORS OF RESTENOSIS IN PATIENTS WITH ISCHEMIC HEART DISEASE AFTER CORONARY STENTING

Abstract

Aim.To analyze the literature data about the role of adiponectin, P-selectin and integrin β3 in the pathogenesis of the development of in-stent restenosis in patients with coronary heart disease after coronary stenting, as well as the possibility of using the listed biomarkers as predictors of restenosis. Results. We examined some aspects of the pathogenesis of the development of in-stent restenosis in patients with coronary heart disease after coronary stenting, including the role of adiponectin, P-selectin and integrin β3, and their prognostic significance. Conclusions. The presented data indicate the probable role of adiponectin, P-selectin and integrin β3 in the pathogenesis of in-stent restenosis development in patients with coronary heart disease after coronary stenting. However, the results of the performed studies, in which the prognostic value of the above biomarkers in respect to the development of restenosis within the stent was evaluated, are contradictory in nature.