INDICATORS OF CYTOKINE STATUS IN INFANTS WITH PERINATAL CNS DAMAGE TO MOTHERS WITH CHRONIC PLACENTAL NSUFFICIENCY

Abstract

Purpose: the study of cytokine status in infants with perinatal CNS damage from mothers with placental insufficiency.Materials and methods: were examined 95 newborns from mothers with chronic kidney disease. Control group – newborns from mothers with physiological pregnancy and childbirth(n = 19). The definition in the cord blood of newborns level of IL-6, TNF-alpha, IFN-g, IL-1β, IL-4 were performed by the method of enzyme immunoassay with the use of diagnostic kits “Cytokine”, St. Petersburg.Results: for children from an early manifestation of perinatal Central nervous system from mothers with decompensated chronic kidney failure, by the increase in cord blood levels of IL-6, IL-1β, TNF-alpha , IFN-g, For children delayed manifestation of perinatal Central nervous system from mothers with asthma, chronic kidney failure, by the increase in the level of IL -6, TNFalpha, IL -4, IFN-g. For children, delayed manifestation of perinatal Central nervous system from mothers with compensated chronic kidney failure, by the increase in the level of IL -4, IFN-g, IL-6.Summary: the development of perinatal CNS damage in newborns from mothers with chronic kidney disease associated with the violation of cytokine balance in cord blood, with a tendency to focus on Th1-type, which promotes the formation of inflammatory mode immune regulation.

Keywords

• placental insufficiency, perinatal cns, newborns