Muskelin regulates actin-dependent synaptic changes and intrinsic brain activity relevant to behavioral and cognitive processes

Mary Muhia; PingAn YuanXiang; Jan Sedlacik; Jürgen R. Schwarz; Frank F. Heisler; Kira V. Gromova; Edda Thies; Petra Breiden; Yvonne Pechmann; Michael R. Kreutz; Matthias Kneussel

doi:10.1038/s42003-022-03446-1

Communications Biology (Jun 2022)

Muskelin regulates actin-dependent synaptic changes and intrinsic brain activity relevant to behavioral and cognitive processes

Mary Muhia,
PingAn YuanXiang,
Jan Sedlacik,
Jürgen R. Schwarz,
Frank F. Heisler,
Kira V. Gromova,
Edda Thies,
Petra Breiden,
Yvonne Pechmann,
Michael R. Kreutz,
Matthias Kneussel

Affiliations

Mary Muhia: Institute of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf
PingAn YuanXiang: RG Neuroplasticity Leibniz Institute for Neurobiology
Jan Sedlacik: Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf
Jürgen R. Schwarz: Institute of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf
Frank F. Heisler: Institute of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf
Kira V. Gromova: Institute of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf
Edda Thies: Institute of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf
Petra Breiden: Institute of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf
Yvonne Pechmann: Institute of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf
Michael R. Kreutz: RG Neuroplasticity Leibniz Institute for Neurobiology
Matthias Kneussel: Institute of Molecular Neurogenetics, Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf

DOI: https://doi.org/10.1038/s42003-022-03446-1
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 18

Abstract

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A murine muskelin knockout induces increased exploratory drive and alters cognition and functional connectivity. These effects correlate with actin-dependent changes in dendritic branching, spine structure, and AMPAR-mediated synaptic transmission.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal