Snps detected in the sirt1 and h-fabp genes and their association with growth traits in yak

Abstract

The aims of this study were to investigate whether the Sirtuin 1 (SIRT1) and Hear fatty acid binding protein (H-FABP) genes could be used as candidate genes in the breeding of yak. In 409 indigenous Chinese yaks, two single nucleotide polymorphisms (SNPs) were identified through DNA sequencing technology, including a SNP within the 5"UTR of SIRT1 (g.1906A>G), and a SNP in the exon 1 of H-FABP (g.6643C>T). The chi-square test suggested that all the variations were in Hardy-Weinberg equilibrium (P>0.05). An association analysis suggested that g.1906A>G of SIRT1 gene and g.6643C>T of H-FABP gene exhibited significant correlation with body weight and body length (P<0.01). These results indicated that these SNPs could be used as meritorious and available genetic markers in yak growth traits breeding.

Keywords

• sirt1 gene
• h-fabp gene
• growth traits
• yak
• single nucleotide polymorphism