Nature Communications (Nov 2022)
Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure
- Michael G. Levin,
- Noah L. Tsao,
- Pankhuri Singhal,
- Chang Liu,
- Ha My T. Vy,
- Ishan Paranjpe,
- Joshua D. Backman,
- Tiffany R. Bellomo,
- William P. Bone,
- Kiran J. Biddinger,
- Qin Hui,
- Ozan Dikilitas,
- Benjamin A. Satterfield,
- Yifan Yang,
- Michael P. Morley,
- Yuki Bradford,
- Megan Burke,
- Nosheen Reza,
- Brian Charest,
- Regeneron Genetics Center,
- Renae L. Judy,
- Megan J. Puckelwartz,
- Hakon Hakonarson,
- Atlas Khan,
- Leah C. Kottyan,
- Iftikhar Kullo,
- Yuan Luo,
- Elizabeth M. McNally,
- Laura J. Rasmussen-Torvik,
- Sharlene M. Day,
- Ron Do,
- Lawrence S. Phillips,
- Patrick T. Ellinor,
- Girish N. Nadkarni,
- Marylyn D. Ritchie,
- Zoltan Arany,
- Thomas P. Cappola,
- Kenneth B. Margulies,
- Krishna G. Aragam,
- Christopher M. Haggerty,
- Jacob Joseph,
- Yan V. Sun,
- Benjamin F. Voight,
- Scott M. Damrauer
Affiliations
- Michael G. Levin
- Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania
- Noah L. Tsao
- Department of Surgery, University of Pennsylvania Perelman School of Medicine
- Pankhuri Singhal
- Department of Genetics, University of Pennsylvania Perelman School of Medicine
- Chang Liu
- Department of Epidemiology, Rollins School of Public Health, Emory University
- Ha My T. Vy
- The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Ishan Paranjpe
- Department of Medicine, Stanford University School of Medicine
- Joshua D. Backman
- Regeneron Genetics Center
- Tiffany R. Bellomo
- Department of Surgery, University of Pennsylvania Perelman School of Medicine
- William P. Bone
- Genomics and Computational Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania
- Kiran J. Biddinger
- Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School
- Qin Hui
- Emory University School of Public Health
- Ozan Dikilitas
- Departments of Internal Medicine and Cardiovascular Medicine, and Mayo Clinician-Investigator Training Program, Mayo Clinic
- Benjamin A. Satterfield
- Department of Cardiovascular Medicine, Mayo Clinic
- Yifan Yang
- Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania
- Michael P. Morley
- Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania
- Yuki Bradford
- Department of Genetics, University of Pennsylvania Perelman School of Medicine
- Megan Burke
- Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania
- Nosheen Reza
- Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania
- Brian Charest
- Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System
- Regeneron Genetics Center
- Renae L. Judy
- Department of Surgery, University of Pennsylvania Perelman School of Medicine
- Megan J. Puckelwartz
- Department of Pharmacology, Center for Genetic Medicine, Northwestern University Feinberg School of Medicine
- Hakon Hakonarson
- Center for Applied Genomics, The Children’s Hospital of Philadelphia
- Atlas Khan
- Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University
- Leah C. Kottyan
- Department of Pediatrics, Division of Human Genetics and Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center
- Iftikhar Kullo
- Department of Cardiovascular Medicine, Mayo Clinic
- Yuan Luo
- Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University
- Elizabeth M. McNally
- Center for Genetic Medicine, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine
- Laura J. Rasmussen-Torvik
- Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
- Sharlene M. Day
- Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania
- Ron Do
- The Charles Bronfman Institute for Personalized Medicine, BioMe Phenomics Center, and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
- Lawrence S. Phillips
- Atlanta VA Health Care System
- Patrick T. Ellinor
- Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard
- Girish N. Nadkarni
- Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai
- Marylyn D. Ritchie
- Department of Genetics, University of Pennsylvania Perelman School of Medicine
- Zoltan Arany
- Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania
- Thomas P. Cappola
- Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania
- Kenneth B. Margulies
- Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania
- Krishna G. Aragam
- Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School
- Christopher M. Haggerty
- Department of Translational Data Science and Informatics and Heart Institute, Geisinger
- Jacob Joseph
- Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System
- Yan V. Sun
- Emory University School of Public Health
- Benjamin F. Voight
- Department of Genetics, University of Pennsylvania Perelman School of Medicine
- Scott M. Damrauer
- Corporal Michael J. Crescenz VA Medical Center
- DOI
- https://doi.org/10.1038/s41467-022-34216-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Heart failure is a major cause of cardiovascular morbidity and mortality. Here, the authors report results of a genome-wide association study meta-analysis, characterizing the role of common genetic variants in heart failure, finding overlap with common cardiovascular risk factors and imaging measures of cardiac structure/function.
