Nature Communications (Dec 2016)
A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation
- Christopher C. Stobart,
- Christina A. Rostad,
- Zunlong Ke,
- Rebecca S. Dillard,
- Cheri M. Hampton,
- Joshua D. Strauss,
- Hong Yi,
- Anne L. Hotard,
- Jia Meng,
- Raymond J. Pickles,
- Kaori Sakamoto,
- Sujin Lee,
- Michael G. Currier,
- Syed M. Moin,
- Barney S. Graham,
- Marina S. Boukhvalova,
- Brian E. Gilbert,
- Jorge C. G. Blanco,
- Pedro A. Piedra,
- Elizabeth R. Wright,
- Martin L. Moore
Affiliations
- Christopher C. Stobart
- Department of Pediatrics, Emory University School of Medicine
- Christina A. Rostad
- Department of Pediatrics, Emory University School of Medicine
- Zunlong Ke
- School of Biology, Georgia Institute of Technology
- Rebecca S. Dillard
- Department of Pediatrics, Emory University School of Medicine
- Cheri M. Hampton
- Department of Pediatrics, Emory University School of Medicine
- Joshua D. Strauss
- Department of Pediatrics, Emory University School of Medicine
- Hong Yi
- Robert P Apkarian Integrated Electron Microscopy Core, Emory University
- Anne L. Hotard
- Department of Pediatrics, Emory University School of Medicine
- Jia Meng
- Department of Pediatrics, Emory University School of Medicine
- Raymond J. Pickles
- Department of Microbiology and Immunology, University of North Carolina
- Kaori Sakamoto
- Department of Pathology, College of Veterinary Medicine, University of Georgia
- Sujin Lee
- Department of Pediatrics, Emory University School of Medicine
- Michael G. Currier
- Department of Pediatrics, Emory University School of Medicine
- Syed M. Moin
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Barney S. Graham
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Marina S. Boukhvalova
- Sigmovir Biosystems Inc.
- Brian E. Gilbert
- Department of Molecular Virology and Microbiology, Baylor College of Medicine
- Jorge C. G. Blanco
- Sigmovir Biosystems Inc.
- Pedro A. Piedra
- Department of Molecular Virology and Microbiology, Baylor College of Medicine
- Elizabeth R. Wright
- Department of Pediatrics, Emory University School of Medicine
- Martin L. Moore
- Department of Pediatrics, Emory University School of Medicine
- DOI
- https://doi.org/10.1038/ncomms13916
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
Development of a safe and efficacious vaccine for respiratory syncytial virus (RSV) has been challenging. Here the authors generate a live-attenuated RSV vaccine that shows increased thermostability and immunogenicity, and protects cotton rats from RSV challenge.
