Autozygosity influences cardiometabolic disease-associated traits in the AWI-Gen sub-Saharan African study

Francisco C. Ceballos; Scott Hazelhurst; David W. Clark; Godfred Agongo; Gershim Asiki; Palwende R. Boua; F. Xavier Gómez-Olivé; Felistas Mashinya; Shane Norris; James F. Wilson; Michèle Ramsay

doi:10.1038/s41467-020-19595-y

Nature Communications (Nov 2020)

Autozygosity influences cardiometabolic disease-associated traits in the AWI-Gen sub-Saharan African study

Francisco C. Ceballos,
Scott Hazelhurst,
David W. Clark,
Godfred Agongo,
Gershim Asiki,
Palwende R. Boua,
F. Xavier Gómez-Olivé,
Felistas Mashinya,
Shane Norris,
James F. Wilson,
Michèle Ramsay

Affiliations

Francisco C. Ceballos: Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
Scott Hazelhurst: Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
David W. Clark: Centre for Global Health Research, Usher Institute, University of Edinburgh
Godfred Agongo: Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
Gershim Asiki: African Population and Health Research Center
Palwende R. Boua: Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
F. Xavier Gómez-Olivé: MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand
Felistas Mashinya: Department of Pathology and Medical Science, School of Health Care Sciences, Faculty of Health Sciences, University of Limpopo
Shane Norris: Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
James F. Wilson: Centre for Global Health Research, Usher Institute, University of Edinburgh
Michèle Ramsay: Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand

DOI: https://doi.org/10.1038/s41467-020-19595-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 8

Abstract

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The prevalence of cardiometabolic diseases (CMDs) is increasing rapidly across Africa. Here, the authors investigate autozygosity in CMD-associated traits in over 10,000 sub-Saharan African individuals, showing these traits are influenced by sex-specific inbreeding depression and environmental interactions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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