Effects of Single and Repeated Oral Doses of Ochratoxin A on the Lipid Peroxidation and Antioxidant Defense Systems in Mouse Kidneys
Szilamér Ferenczi,
Dániel Kuti,
Mátyás Cserháti,
Csilla Krifaton,
Sándor Szoboszlay,
József Kukolya,
Zsuzsanna Szőke,
Mihály Albert,
Balázs Kriszt,
Krisztina J. Kovács,
Miklós Mézes,
Krisztián Balogh
Affiliations
Szilamér Ferenczi
Institute of Experimental Medicine, Laboratory of Molecular Neuroendocrinology, 43. Szigony Street, Budapest 1083, Hungary
Dániel Kuti
Institute of Experimental Medicine, Laboratory of Molecular Neuroendocrinology, 43. Szigony Street, Budapest 1083, Hungary
Mátyás Cserháti
Szent István University, Department of Environmental Protection & Safety, 1. Páter K. Street, Gödöllő 2100, Hungary
Csilla Krifaton
Szent István University, Department of Environmental Protection & Safety, 1. Páter K. Street, Gödöllő 2100, Hungary
Sándor Szoboszlay
Szent István University, Department of Environmental Protection & Safety, 1. Páter K. Street, Gödöllő 2100, Hungary
József Kukolya
Central Environmental and Food Science Research Institute, Department of Microbiology, 15. Herman O. Street, Budapest 1022, Hungary
Zsuzsanna Szőke
National Agricultural Research and Innovation Center, Agricultural Biotechnology Institute, Reproduction Biology and Toxicology Research Group, 4. Szent-Györgyi A. Street, Gödöllő 2100, Hungary
Mihály Albert
CEVA Phylaxia Ltd, 5. Szállás Street, Budapest 1107, Hungary
Balázs Kriszt
Szent István University, Department of Environmental Protection & Safety, 1. Páter K. Street, Gödöllő 2100, Hungary
Krisztina J. Kovács
Institute of Experimental Medicine, Laboratory of Molecular Neuroendocrinology, 43. Szigony Street, Budapest 1083, Hungary
Miklós Mézes
Szent István University, Department of Nutrition, 1. Páter K. Street, Gödöllő 2100, Hungary
Krisztián Balogh
Szent István University, Department of Nutrition, 1. Páter K. Street, Gödöllő 2100, Hungary
Ochratoxin-A (OTA) is a carcinogenic and nephrotoxic mycotoxin, which may cause health problems in humans and animals, and it is a contaminant in foods and feeds. The purpose of the present study is to evaluate the effect of oral OTA exposure on the antioxidant defense and lipid peroxidation in the kidney. In vivo administration of OTA in CD1, male mice (1 or 10 mg/kg body weight in a single oral dose for 24 h and repeated daily oral dose for 72 h or repeated daily oral dose of 0.5 mg/kg bodyweight for 21 days) resulted in a significant elevation of OTA levels in blood plasma. Some histopathological alterations, transcriptional changes in the glutathione system, and oxidative stress response-related genes were also found. In the renal cortex, the activity of the glutathione-system-related enzymes and certain metabolites of the lipid peroxidation (conjugated dienes, trienes, and thiobarbituric reactive substances) also changed.
