Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer

Abstract

G protein-coupled receptors (GPCRs), such as GABAB, can integrate extracellular signals via allosteric interactions within dimers and oligomers. Here authors use crosslinking and identify two transmembrane interfaces in GABAB which undergo a concerted rearrangement upon agonist activation.