Replication dynamics of recombination-dependent replication forks

Karel Naiman; Eduard Campillo-Funollet; Adam T. Watson; Alice Budden; Izumi Miyabe; Antony M. Carr

doi:10.1038/s41467-021-21198-0

Nature Communications (Feb 2021)

Replication dynamics of recombination-dependent replication forks

Karel Naiman,
Eduard Campillo-Funollet,
Adam T. Watson,
Alice Budden,
Izumi Miyabe,
Antony M. Carr

Affiliations

Karel Naiman: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Eduard Campillo-Funollet: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Adam T. Watson: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Alice Budden: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Izumi Miyabe: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Antony M. Carr: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex

DOI: https://doi.org/10.1038/s41467-021-21198-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

Read online

Replication forks that are stalled at obstacles on the DNA template can be restarted by homologous recombination. Here, the authors show replication dynamics during homologous recombination-dependent replication fork restart by combining polymerase usage sequencing and a Monte Carlo mathematical model.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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