Mitochondrial Ca2+ homeostasis in health and disease

Abstract

Although it has long been known that mitochondria possess a complex molecular repertoire for accumulating and releasing Ca2+, only in recent years has a large body of data demonstrated that these organelles promptly respond to Ca2+-mediated cell stimulations. In this contribution, we will review the principles of mitochondrial Ca2+ homeostasis and its signaling role in different physiological and pathological conditions.

Keywords

• Mitochondria
• Calcium
• Apoptosis
• Bcl-2
• viral proteins