Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance

Zhongliang Shen; Huijuan Yang; Sisi Yang; Wei Wang; Xiaoxian Cui; Xian Zhou; Wei Liu; Shaokun Pan; Yanfeng Liu; Junqi Zhang; Jiming Zhang; Youhua Xie; Jing Liu

doi:10.1038/s41467-017-02304-7

Nature Communications (Dec 2017)

Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance

Zhongliang Shen,
Huijuan Yang,
Sisi Yang,
Wei Wang,
Xiaoxian Cui,
Xian Zhou,
Wei Liu,
Shaokun Pan,
Yanfeng Liu,
Junqi Zhang,
Jiming Zhang,
Youhua Xie,
Jing Liu

Affiliations

Zhongliang Shen: Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan University
Huijuan Yang: Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan University
Sisi Yang: Department of Infectious Diseases, Huashan Hospital, Fudan University
Wei Wang: Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan University
Xiaoxian Cui: Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan University
Xian Zhou: Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan University
Wei Liu: Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan University
Shaokun Pan: Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan University
Yanfeng Liu: Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan University
Junqi Zhang: Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan University
Jiming Zhang: Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan University
Youhua Xie: Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan University
Jing Liu: Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, School of Basic Medical Sciences, Shanghai Medical College, Fudan University

DOI: https://doi.org/10.1038/s41467-017-02304-7
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Hepatitis B virus (HBV) establishes chronic infection in only some patients, but the mechanisms underlying clearance failure in these patients are not fully understood. Here, the authors identify and characterize an HBV strain that can persist in mice and show that IL-21 and IL-33 responses contribute to clearance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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