Experimental substantiation of the use of a small dose of the vaccine to prevent the specific brucellosis of cattle

Abstract

The expansion of zones with the cattle without anti-brucellosis immunity in healthy areas increases the risk of cattle infection from neighboring infected regions and states. There is an urgent problem of developing the anti-brucellosis immunity in the adult cattle. The initial full-dose vaccination with the vaccine from strain B. abortus 82 is fraught with post-vaccination abortion. The study is aimed at the exploration of the immune response and immunity in cows vaccinated against brucellosis according to different schemes with small doses of vaccines from B. abortus strains 19 and 82. The results of the experiment showed that the small-dose revaccination with a vaccine from strain 82 is the most promising, because without any harm to the formed immunity, the problem associated with the reactogenicity and agglutinogenicity of the vaccine can be solved. In addition, a ten-time reduction in the vaccine dose can reduce vaccine production volumes and decrease financial expenses of the farmers.