Nature Communications (Jul 2020)
Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis
- Luca Muzio,
- Riccardo Sirtori,
- Davide Gornati,
- Simona Eleuteri,
- Andrea Fossaghi,
- Diego Brancaccio,
- Leonardo Manzoni,
- Linda Ottoboni,
- Luca De Feo,
- Angelo Quattrini,
- Eloise Mastrangelo,
- Luca Sorrentino,
- Emanuele Scalone,
- Giancarlo Comi,
- Luciana Marinelli,
- Nilo Riva,
- Mario Milani,
- Pierfausto Seneci,
- Gianvito Martino
Affiliations
- Luca Muzio
- INSPE—Institute of Experimental Neurology, San Raffaele Scientific Institute
- Riccardo Sirtori
- INSPE—Institute of Experimental Neurology, San Raffaele Scientific Institute
- Davide Gornati
- Department of Chemistry, University of Milan
- Simona Eleuteri
- INSPE—Institute of Experimental Neurology, San Raffaele Scientific Institute
- Andrea Fossaghi
- INSPE—Institute of Experimental Neurology, San Raffaele Scientific Institute
- Diego Brancaccio
- Department of Pharmacy, University of Naples “Federico II”
- Leonardo Manzoni
- Institute of Molecular Science and Technology (ISTM), CNR
- Linda Ottoboni
- INSPE—Institute of Experimental Neurology, San Raffaele Scientific Institute
- Luca De Feo
- INSPE—Institute of Experimental Neurology, San Raffaele Scientific Institute
- Angelo Quattrini
- INSPE—Institute of Experimental Neurology, San Raffaele Scientific Institute
- Eloise Mastrangelo
- Institute of Biophysics (IBF), CNR
- Luca Sorrentino
- Institute of Biophysics (IBF), CNR
- Emanuele Scalone
- Department of Chemistry, University of Milan
- Giancarlo Comi
- INSPE—Institute of Experimental Neurology, San Raffaele Scientific Institute
- Luciana Marinelli
- Department of Pharmacy, University of Naples “Federico II”
- Nilo Riva
- INSPE—Institute of Experimental Neurology, San Raffaele Scientific Institute
- Mario Milani
- Institute of Biophysics (IBF), CNR
- Pierfausto Seneci
- Department of Chemistry, University of Milan
- Gianvito Martino
- INSPE—Institute of Experimental Neurology, San Raffaele Scientific Institute
- DOI
- https://doi.org/10.1038/s41467-020-17524-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 17
Abstract
ALS is a neurodegenerative disease characterized by loss of motor neurons. Here, the authors showed that reduced levels of the VSP35 subunit in the retromer complex is a conserved ALS feature and identified a new lead compound increasing retromer stability ameliorating the disease phenotype.
