Changing epidemiological trends of inflammatory bowel disease in Asia

Intestinal Research. 2016;14(2):111-119 DOI 10.5217/ir.2016.14.2.111

 

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Journal Title: Intestinal Research

ISSN: 1598-9100 (Print); 2288-1956 (Online)

Publisher: Korean Association for the Study of Intestinal Diseases

Society/Institution: Asian Organization for Crohn's and Colitis

LCC Subject Category: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology

Country of publisher: Korea, Republic of

Language of fulltext: English

Full-text formats available: PDF, HTML, XML

 

AUTHORS

Wee Khoon Ng (Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Diseases and LKS Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China.)
Sunny H. Wong (Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Diseases and LKS Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China.)
Siew C. Ng (Department of Medicine and Therapeutics, Institute of Digestive Disease, State Key Laboratory of Digestive Diseases and LKS Institute of Health Science, The Chinese University of Hong Kong, Hong Kong, China.)

EDITORIAL INFORMATION

Peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 38 weeks

 

Abstract | Full Text

Inflammatory bowel disease (IBD) has become more common in Asia over the past few decades. The rate of increase in prevalence of the disease varies greatly in Asia, with several countries in East Asia experiencing a more than doubled increase in IBD prevalence over the past decade. Historically, ulcerative colitis (UC) is more common than Crohn's disease (CD) in Asia. However, a reverse trend is beginning to appear in more developed countries in Asia such as Japan, Korea, and Hong Kong. While Asian IBD patients share many similarities with their Western counterparts, there are important differences with significant clinical implications. In Asia, there are more men with CD, more ileo-colonic involvement in CD, less familial aggregation, fewer extra-intestinal manifestations and worse clinical outcomes for older-onset patients with UC. These differences are likely related to the different genetic makeup and environmental exposures in different regions. Evaluation of the differences and rates in epidemiologic trends may help researchers and clinicians estimate disease burden and understand the reasons behind these differences, which may hold the key to unravel the etiology of IBD.