Fatty acid and lipidomic data in normal and tumor colon tissues of rats fed diets with and without fish oil
Zora Djuric,
Muhammad Nadeem Aslam,
Becky R. Simon,
Ananda Sen,
Yan Jiang,
Jianwei Ren,
Rena Chan,
Tanu Soni,
Thekkelnaycke M. Rajendiran,
William L. Smith,
Dean E. Brenner
Affiliations
Zora Djuric
Department of Family Medicine, University of Michigan, Ann Arbor, MI 48109, United States; Corresponding author.
Muhammad Nadeem Aslam
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, United States
Becky R. Simon
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, United States
Ananda Sen
Department of Family Medicine, University of Michigan, Ann Arbor, MI 48109, United States; Departments of Statistics, University of Michigan, Ann Arbor, MI 48109, United States
Yan Jiang
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, United States
Jianwei Ren
Department of Family Medicine, University of Michigan, Ann Arbor, MI 48109, United States
Rena Chan
Department of Family Medicine, University of Michigan, Ann Arbor, MI 48109, United States
Tanu Soni
Michigan Metabolomics Resource Center, University of Michigan, Ann Arbor, MI 48109, United States
Thekkelnaycke M. Rajendiran
Michigan Metabolomics Resource Center, University of Michigan, Ann Arbor, MI 48109, United States
William L. Smith
Department of Biochemistry, University of Michigan, Ann Arbor, MI 48109, United States
Dean E. Brenner
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, United States; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, United States
Data is provided to show the detailed fatty acid and lipidomic composition of normal and tumor rat colon tissues. Rats were fed either a Western fat diet or a fish oil diet, and half the rats from each diet group were treated with chemical carcinogens that induce colon cancer (azoxymethane and dextran sodium sulfate). The data show total fatty acid profiles of sera and of all the colon tissues, namely normal tissue from control rats and both normal and tumor tissues from carcinogen-treated rats, as obtained by gas chromatography with mass spectral detection. Data from lipidomic analyses of a representative subset of the colon tissue samples is also shown in heat maps generated from hierarchical cluster analysis. These data display the utility lipidomic analyses to enhance the interpretation of dietary feeding studies aimed at cancer prevention and support the findings published in the companion paper (Effects of fish oil supplementation on prostaglandins in normal and tumor colon tissue: modulation by the lipogenic phenotype of colon tumors, Djuric et al., 2017 [1]). Keywords: Fatty acids, Colon tumorigenesis, Diet, Fish oils, Lipidomics
