IL-10 and IL-17 Gene Polymorphisms In Adult Idıopathıc Thrombocytopenıc Purpura

Abstract

Aim:Interleukin 10 (IL-10) and interleukin 17 (il-17) cytokine gene polymorphisms were investigated in many autoimmune diseases and there were significant results in some studies but a few published studies on IL-10 and il-17 gene polymorphisms in idiopathic thrombocytopenic purpura (ITP) were seen in the literature. In this study, we aimed to evaluate the IL-10 (-592 A/C) and IL-17 (A126G) gene polymorphisms and their serum levels in adult patients with ITP.Materials and Methods:The IL-10 (-592 A/C) and IL-17 (A126G) gene polymorphisms in 50 patients with ITP and 51 healthy control groups were determined after DNA isolation and serum levels of these cytokines were measured by ELISA method, in 32 patients with ITP in the same group and 32 healthy volunteers.Results:There was no statistically significant difference in IL-10 (-592 A/C) and IL-17 (A126G) gene polymorphisms between the patients and control groups, whereas serum IL-10 levels were found to be statistically significant higher in ITP patients than control group (p=0.003). Serum IL-17 levels were similar in patients and control groups. In addition, age, sex, response to treatment and platelet values at diagnosis were compared between the groups, but there was no statistically significant difference.Conclusion:In our study, IL-10 (-592 A/C) and IL-17 (A126G) gene polymorphisms were not found to be different in patients with ITP compared to healthy subjects, although IL-10 levels were found to be higher in the ITP group than healthy group. When we look the datas in the literature, we thought that more studies with larger series are needed in this field in order to clarify the importance of cytokines in the diagnosis and follow-up of ITP.

Keywords

• immune thrombocytopenic purpura
• interleukin-10
• interleukin -17
• gene polymorphism