Cancer Management and Research (Sep 2021)
lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis
Abstract
Youting Dang,1 Yunping Zhou,2 Xuehai Ou,2 Qiang Wang,2 Dengke Wei,2 Fei Xie2 1Department of Pediatric Orthopedics, Honghui Hospital, Xi’an Jiao Tong University, Xi’an, Shaanxi, 710054, People’s Republic of China; 2Department of Hand Surgery, Honghui Hospital, Xi’an Jiao Tong University, Xi’an, Shaanxi, 710054, People’s Republic of ChinaCorrespondence: Fei XieDepartment of Hand Surgery, Honghui Hospital, Xi’an Jiao Tong University, 555 East Friendship Road, Xi’an, Shaanxi, 710054, People’s Republic of ChinaEmail [email protected]: Long non-coding RNAs (lncRNAs) have been implicated in initiation and development of numerous cancers. In the present study, we explored the role of lncRNAs AC007207.2 in osteosarcoma (OS).Methods: Gene expression data of OS tissues was downloaded from the TARGET database. All the experiments were repeated at least three times. Data were analyzed using Perl, R, SPSS v12.0 and GraphPad Prism 8 software.Results: We found lncRNA AC007207.2 was over-expressed in OS tissues and cell lines, and this phenomenon was associated with the worse prognosis of OS. Moreover, we found that AC007207.2 promotes proliferation and metastasis of OS cells via the miR-1306-5p/SIRT7 axis. Meanwhile, we found miR-1306-5p remarkably inhibits the malignant behavior of OS cells.Conclusion: lncRNA AC007207.2 promotes progression of OS by upregulating SIRT7 expression through miR-1306-5p sponging. Thus, lncRNA AC007207.2/miR-1306-5p/SIRT7 axis is a promising therapeutic target for OS treatment.Keywords: LncRNA AC007207.2, osteosarcoma, miRNA
