Frontiers in Pharmacology (Jan 2011)

Microsomal prostaglandin E synthase-1 in rheumatic diseases

  • Marina eKorotkova,
  • Marina eKorotkova,
  • Per Johan Jakobsson

DOI
https://doi.org/10.3389/fphar.2010.00146
Journal volume & issue
Vol. 1

Abstract

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Microsomal prostaglandin E synthase-1 (mPGES-1) is a well recognized target for the development of novel anti-inflammatory drugs that can reduce symptoms of inflammation in rheumatic diseases and other inflammatory conditions. In this review, we focus on mPGES-1 in rheumatic diseases with the aim to cover the most recent advances in the understanding of mPGES-1 in rheumatoid arthritis, osteoarthritis and inflammatory myopathies. Novel findings regarding regulation of mPGES1 cell expression as well as enzyme inhibitors are also summarized.

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