Research progress of programmed cell death in the occurrence and development of sepsis

Abstract

Sepsis has high morbidity and mortality in critically ill patients.The occurrence and development of sepsis will lead to programmed cell death. All kinds of programmed cell death mediate inflammatory response and oxidative stress through different signal transduction pathways, and cause irreversible damage in patients with sepsis, and finally develop into multiple organ failure. At present, programmed cell death has been found, including apoptosis, necroptosis, pyroptosis, ferroptosis and so on. The development and progression of sepsis is accompanied by various types of programmed cell death.These results of research provide new ideas for exploring the pathophysiological mechanism of sepsis and strategies of clinical treatment.

Keywords

• sepsis|apoptosis|programmed cell death|pyroptosis|ferroptosis