A Study of the Tumor Necrotizing Effects with S. Marcenscens Polysaccharide in Mice Transplanted Sarcomas (S-37)

Abstract

Mice bearing sarcoma implants (S.37) obtained from the National Câncer Institute received sublethal dosage of Serrata Marcenscens polysaccharide (as obtained from Dr. Shear). The cytotoxic like action, characterized by hemorrhage and necrosis in the tumor mass has been investigated, as to its relationship to an anaphylactic action, or as due to an increased capillary fragility. Results are herewith reported.

Keywords

• Neoplasms/complications
• Necrosis
• Polysaccharides/adverse effects
• Tumor Necrosis Factors