Communications Biology (Feb 2022)
The neuroprotective mechanism of lithium after ischaemic stroke
- Beina Chen,
- Manman Zhang,
- Ming Ji,
- Dianjun Zhang,
- Binjie Chen,
- Wenliang Gong,
- Xinyu Li,
- Yuefei Zhou,
- Chengyi Dong,
- Gehua Wen,
- Xiaoni Zhan,
- Xiafang Wu,
- Huiya Yuan,
- Enyu Xu,
- Maosheng Xia,
- Alexei Verkhratsky,
- Baoman Li
Affiliations
- Beina Chen
- Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University
- Manman Zhang
- Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University
- Ming Ji
- Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University
- Dianjun Zhang
- Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University
- Binjie Chen
- Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University
- Wenliang Gong
- Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University
- Xinyu Li
- Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University
- Yuefei Zhou
- Department of Orthopaedics, The First Hospital, China Medical University
- Chengyi Dong
- Department of Orthopaedics, The First Hospital, China Medical University
- Gehua Wen
- Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University
- Xiaoni Zhan
- Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University
- Xiafang Wu
- Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University
- Huiya Yuan
- Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University
- Enyu Xu
- Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University
- Maosheng Xia
- Department of Orthopaedics, The First Hospital, China Medical University
- Alexei Verkhratsky
- Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University
- Baoman Li
- Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University
- DOI
- https://doi.org/10.1038/s42003-022-03051-2
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 14
Abstract
Using the MCAO stroke mouse model, Chen et al. identify pathways that underlie the neuroprotective properties of lithium by using inhibitors of AKT/GSK3β/β-catenin and AKT/FoxO3a/β-catenin signaling. They report that the inhibitors reverse the protective effects of lithium thus conclude that both pathways are key for lithium-mediated neuroprotection.
