Inferring differential subcellular localisation in comparative spatial proteomics using BANDLE

Oliver M. Crook; Colin T. R. Davies; Lisa M. Breckels; Josie A. Christopher; Laurent Gatto; Paul D. W. Kirk; Kathryn S. Lilley

doi:10.1038/s41467-022-33570-9

Nature Communications (Oct 2022)

Inferring differential subcellular localisation in comparative spatial proteomics using BANDLE

Oliver M. Crook,
Colin T. R. Davies,
Lisa M. Breckels,
Josie A. Christopher,
Laurent Gatto,
Paul D. W. Kirk,
Kathryn S. Lilley

Affiliations

Oliver M. Crook: Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge
Colin T. R. Davies: Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge
Lisa M. Breckels: Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge
Josie A. Christopher: Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge
Laurent Gatto: de Duve Institute, Université catholique de Louvain
Paul D. W. Kirk: MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge
Kathryn S. Lilley: Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge

DOI: https://doi.org/10.1038/s41467-022-33570-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 21

Abstract

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Changes in protein subcellular localization can be determined using mass spectrometry. Here, the authors present a statistical approach to determine relocalising proteins from spatial proteomics experiments.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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