Nature Communications (Nov 2018)
Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA
- Julius Gudmundsson,
- Jon K. Sigurdsson,
- Lilja Stefansdottir,
- Bjarni A. Agnarsson,
- Helgi J. Isaksson,
- Olafur A. Stefansson,
- Sigurjon A. Gudjonsson,
- Daniel F. Gudbjartsson,
- Gisli Masson,
- Michael L. Frigge,
- Simon N. Stacey,
- Patrick Sulem,
- Gisli H. Halldorsson,
- Vinicius Tragante,
- Hilma Holm,
- Gudmundur I. Eyjolfsson,
- Olof Sigurdardottir,
- Isleifur Olafsson,
- Thorvaldur Jonsson,
- Eirikur Jonsson,
- Rosa B. Barkardottir,
- Rafn Hilmarsson,
- Folkert W. Asselbergs,
- Gudmundur Geirsson,
- Unnur Thorsteinsdottir,
- Thorunn Rafnar,
- Gudmar Thorleifsson,
- Kari Stefansson
Affiliations
- Julius Gudmundsson
- deCODE genetics/AMGEN
- Jon K. Sigurdsson
- deCODE genetics/AMGEN
- Lilja Stefansdottir
- deCODE genetics/AMGEN
- Bjarni A. Agnarsson
- Landspitali-University Hospital
- Helgi J. Isaksson
- Landspitali-University Hospital
- Olafur A. Stefansson
- deCODE genetics/AMGEN
- Sigurjon A. Gudjonsson
- deCODE genetics/AMGEN
- Daniel F. Gudbjartsson
- deCODE genetics/AMGEN
- Gisli Masson
- deCODE genetics/AMGEN
- Michael L. Frigge
- deCODE genetics/AMGEN
- Simon N. Stacey
- deCODE genetics/AMGEN
- Patrick Sulem
- deCODE genetics/AMGEN
- Gisli H. Halldorsson
- deCODE genetics/AMGEN
- Vinicius Tragante
- deCODE genetics/AMGEN
- Hilma Holm
- deCODE genetics/AMGEN
- Gudmundur I. Eyjolfsson
- The Clinical Laboratory in Mjodd
- Olof Sigurdardottir
- Department of Clinical Biochemistry, Akureyri Hospital
- Isleifur Olafsson
- Landspitali-University Hospital
- Thorvaldur Jonsson
- Landspitali-University Hospital
- Eirikur Jonsson
- Landspitali-University Hospital
- Rosa B. Barkardottir
- Laboratory of Cell Biology, Department of Pathology, Landspitali University Hospital
- Rafn Hilmarsson
- Landspitali-University Hospital
- Folkert W. Asselbergs
- Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht
- Gudmundur Geirsson
- Landspitali-University Hospital
- Unnur Thorsteinsdottir
- deCODE genetics/AMGEN
- Thorunn Rafnar
- deCODE genetics/AMGEN
- Gudmar Thorleifsson
- deCODE genetics/AMGEN
- Kari Stefansson
- deCODE genetics/AMGEN
- DOI
- https://doi.org/10.1038/s41467-018-06920-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 8
Abstract
Elderly males are often affected by benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS), but their link to prostate cancer risk is not well defined. Here, a genome-wide association study of BPH/LUTS patients from Iceland and the UK found 23 significant variants at 14 loci, and 15 of these variants associate with prostate specific antigen, which is linked to prostate cancer risk.
