Nature Communications (Jan 2018)

AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis

  • Matt Teater,
  • Pilar M. Dominguez,
  • David Redmond,
  • Zhengming Chen,
  • Daisuke Ennishi,
  • David W. Scott,
  • Luisa Cimmino,
  • Paola Ghione,
  • Jayanta Chaudhuri,
  • Randy D. Gascoyne,
  • Iannis Aifantis,
  • Giorgio Inghirami,
  • Olivier Elemento,
  • Ari Melnick,
  • Rita Shaknovich

DOI
https://doi.org/10.1038/s41467-017-02595-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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In diffuse large B-cell lymphoma (DLBCL) increased epigenetic heterogeneity in the form of cytosine methylation is known to link to a poor clinical outcome. Here, the authors show that AICDA, an enzyme required for DLBCL pathogenesis, increases cytosine methylation heterogeneity.