Journal of Translational Medicine (Jan 2024)

Emerging applications of single-cell profiling in precision medicine of atherosclerosis

  • Huiling Lin,
  • Ming Zhang,
  • Mi Hu,
  • Yangkai Zhang,
  • WeiWei Jiang,
  • Wanying Tang,
  • Yuxin Ouyang,
  • Liping Jiang,
  • Yali Mi,
  • Zhi Chen,
  • Pingping He,
  • Guojun Zhao,
  • Xinping Ouyang

DOI
https://doi.org/10.1186/s12967-023-04629-y
Journal volume & issue
Vol. 22, no. 1
pp. 1 – 14

Abstract

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Abstract Atherosclerosis is a chronic, progressive, inflammatory disease that occurs in the arterial wall. Despite recent advancements in treatment aimed at improving efficacy and prolonging survival, atherosclerosis remains largely incurable. In this review, we discuss emerging single-cell sequencing techniques and their novel insights into atherosclerosis. We provide examples of single-cell profiling studies that reveal phenotypic characteristics of atherosclerosis plaques, blood, liver, and the intestinal tract. Additionally, we highlight the potential clinical applications of single-cell analysis and propose that combining this approach with other techniques can facilitate early diagnosis and treatment, leading to more accurate medical interventions.

Keywords