Nature Communications (Nov 2018)
BMI1 enables interspecies chimerism with human pluripotent stem cells
- Ke Huang,
- Yanling Zhu,
- Yanlin Ma,
- Bentian Zhao,
- Nana Fan,
- Yuhang Li,
- Hong Song,
- Shilong Chu,
- Zhen Ouyang,
- Quanjun Zhang,
- Qi Xing,
- Chengdan Lai,
- Nan Li,
- Tian Zhang,
- Jiaming Gu,
- Baoqiang Kang,
- Yongli Shan,
- Keyu Lai,
- Wenhao Huang,
- Yuchan Mai,
- Qing Wang,
- Jinbing Li,
- Aiping Lin,
- Yanqi Zhang,
- Xiaofen Zhong,
- Baojian Liao,
- Liangxue Lai,
- Jiekai Chen,
- Duanqing Pei,
- Guangjin Pan
Affiliations
- Ke Huang
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Yanling Zhu
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Yanlin Ma
- Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University
- Bentian Zhao
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Nana Fan
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Yuhang Li
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Hong Song
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Shilong Chu
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Zhen Ouyang
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Quanjun Zhang
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Qi Xing
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Chengdan Lai
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Nan Li
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Tian Zhang
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Jiaming Gu
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Baoqiang Kang
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Yongli Shan
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Keyu Lai
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Wenhao Huang
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Yuchan Mai
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Qing Wang
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Jinbing Li
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Aiping Lin
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Yanqi Zhang
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Xiaofen Zhong
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Baojian Liao
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Liangxue Lai
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Jiekai Chen
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Duanqing Pei
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- Guangjin Pan
- Key Laboratory of Regenerative Biology of Chinese Academy of Sciences, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University
- DOI
- https://doi.org/10.1038/s41467-018-07098-w
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Conventional human pluripotent stem cells (hPSCs) fail to contribute to interspecies chimaeras when injected into mouse blastocysts. Here the authors show that forced expression of BMI1 overcomes apoptosis of hPSCs in blastocysts of mouse, rabbit and pig allowing them to contribute to chimaeras.
