Hormetic Effect of HO in

Abstract

In this study, we investigated the relationship between target of rapamycin (TOR) and H 2 O 2 -induced hormetic response in the budding yeast Saccharomyces cerevisiae grown on glucose or fructose. In general, our data suggest that: (1) hydrogen peroxide (H 2 O 2 ) induces hormesis in a TOR-dependent manner; (2) the H 2 O 2 -induced hormetic dose–response in yeast depends on the type of carbohydrate in growth medium; (3) the concentration-dependent effect of H 2 O 2 on yeast colony growth positively correlates with the activity of glutathione reductase that suggests the enzyme involvement in the H 2 O 2 -induced hormetic response; and (4) both TOR1 and TOR2 are involved in the reciprocal regulation of the activity of glucose-6-phosphate dehydrogenase and glyoxalase 1.