Microfluidic Device Directly Fabricated on Screen-Printed Electrodes for Ultrasensitive Electrochemical Sensing of PSA

Shouhui Chen; Zhihua Wang; Xinyuan Cui; Linlei Jiang; Yuee Zhi; Xianting Ding; Zhihong Nie; Pei Zhou; Daxiang Cui

doi:10.1186/s11671-019-2857-6

Nanoscale Research Letters (Feb 2019)

Microfluidic Device Directly Fabricated on Screen-Printed Electrodes for Ultrasensitive Electrochemical Sensing of PSA

Shouhui Chen,
Zhihua Wang,
Xinyuan Cui,
Linlei Jiang,
Yuee Zhi,
Xianting Ding,
Zhihong Nie,
Pei Zhou,
Daxiang Cui

Affiliations

Shouhui Chen: Center of Food Safety Engineering and Technology Research, Shanghai, Key Laboratory of Urban Agriculture, Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University
Zhihua Wang: Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Center for Intelligent Instrument for Diagnosis and Therapy, Key Lab. for Thin Film and Microfabrication Technology of Ministry of Education, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University
Xinyuan Cui: Department of Medical Imaging, Second Clinical College of Chongqing Medical University
Linlei Jiang: Center of Food Safety Engineering and Technology Research, Shanghai, Key Laboratory of Urban Agriculture, Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University
Yuee Zhi: Center of Food Safety Engineering and Technology Research, Shanghai, Key Laboratory of Urban Agriculture, Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University
Xianting Ding: Institute for Personalized Medicine, School of Biomedical Engineering, Shanghai Jiao Tong University
Zhihong Nie: Department of Chemistry and Biochemistry, University of Maryland
Pei Zhou: Center of Food Safety Engineering and Technology Research, Shanghai, Key Laboratory of Urban Agriculture, Ministry of Agriculture, School of Agriculture and Biology, Shanghai Jiao Tong University
Daxiang Cui: Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Center for Intelligent Instrument for Diagnosis and Therapy, Key Lab. for Thin Film and Microfabrication Technology of Ministry of Education, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University

DOI: https://doi.org/10.1186/s11671-019-2857-6
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 7

Abstract

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Abstract How to fabricate scale low-cost microfluidic device for detection of biomarkers owns a great requirement. Herein, it is for the first time reported that a new microfluidic device based on bonding polydimethylsiloxane microfluidic channels onto the substrate of a screen-printed electrode with coating glass solution was fabricated for electrochemical sensing of prostate-specific antigen (PSA). Compared to traditional microfabrication processes, this method is simple, fast, low cost, and also suitable for mass production. The prepared screen-printed electrode-based microfluidic device (CASPE-MFD) was used for the detection of the PSA in human serum. The prepared CASPE-MFD had a detection limit of 0.84 pg/mL (25.8 fM) and a good linearity with PSA concentration ranging from 0.001 to 10 ng/mL, which showed a great promise platform toward the development of miniaturized, low-cost electrochemical microfluidic device for use in human health, environmental monitoring, and other applications.

Published in Nanoscale Research Letters

ISSN: 1931-7573 (Print); 1556-276X (Online)
Publisher: SpringerOpen
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.springer.com/journal/11671

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