Serum Soluble Transferrin Receptor and Transferrin Levels among Regular Blood Donors

Samuel K. Appiah; Simon B. Bani; Charles Nkansah; Kofi Mensah; Gabriel Abbam; Felix Osei-Boakye; Samira Daud; Charles A. Derigubah; Christopher Nkrumah; Dorcas Serwaa; Vincent Kawuribi; Deborah E. Nkansah; Benjamin O. Opoku; Catherine A. Avero; Yeduah Quansah; Candy A. E. Wilson; Felix E. Chukwurah

doi:10.28991/SciMedJ-2022-04-03-01

SciMedicine Journal (Sep 2022)

Serum Soluble Transferrin Receptor and Transferrin Levels among Regular Blood Donors

Samuel K. Appiah,
Simon B. Bani,
Charles Nkansah,
Kofi Mensah,
Gabriel Abbam,
Felix Osei-Boakye,
Samira Daud,
Charles A. Derigubah,
Christopher Nkrumah,
Dorcas Serwaa,
Vincent Kawuribi,
Deborah E. Nkansah,
Benjamin O. Opoku,
Catherine A. Avero,
Yeduah Quansah,
Candy A. E. Wilson,
Felix E. Chukwurah

Affiliations

Samuel K. Appiah: 1) Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana. 2) Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, Ebonyi State University, Abakaliki,
Simon B. Bani: Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale,
Charles Nkansah: 1) Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana. 2) Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, Ebonyi State University, Abakaliki,
Kofi Mensah: 1) Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana. 2) Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, Ebonyi State University, Abakaliki,
Gabriel Abbam: Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale,
Felix Osei-Boakye: Department of Medical Laboratory Technology, Faculty of Applied Science and Technology, Sunyani Technical University, Sunyani,
Samira Daud: Department of Haematology, School of Allied Health Sciences, University for Development Studies, Tamale,
Charles A. Derigubah: Department of Medical Laboratory Technology, School of Applied Science and Arts, Bolgatanga Technical University, Bolgatanga,
Christopher Nkrumah: 3) Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale, Ghana. 6) Department of Medical Laboratory, Methodist Hospital, Wenchi,
Dorcas Serwaa: Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne,
Vincent Kawuribi: Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale,
Deborah E. Nkansah: Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale,
Benjamin O. Opoku: Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale,
Catherine A. Avero: Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale,
Yeduah Quansah: Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale,
Candy A. E. Wilson: Department of Biomedical Laboratory Sciences, School of Allied Health Sciences, University for Development Studies, Tamale,
Felix E. Chukwurah: Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, Ebonyi State University, Abakaliki,

DOI: https://doi.org/10.28991/SciMedJ-2022-04-03-01
Journal volume & issue: Vol. 4, no. 3
pp. 101 – 110

Abstract

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Background: The study evaluated the effects of regular blood donation on serum transferrin and soluble transferrin receptor levels at Wenchi Methodist Hospital. Methods: This was a hospital-based cross-sectional study conducted at the Medical Laboratory Department of the Wenchi Methodist Hospital in the Bono Region of Ghana. A total of eighty-nine (89) venous blood samples from apparently healthy blood donors were analyzed. Complete blood count parameters were analyzed using an automated haematology analyzer and serum transferrin and transferrin receptor using ELISA. The data were analyzed using SPSS version 22.0. Results: Haemoglobin (p<0.001) and HCT (p=0.004) were significantly lower among the regular blood donors compared with the first-time donors. Regular blood donors had relatively higher serum transferrin (p<0.001) and soluble transferrin receptor levels (p<0.001). A negative correlation was observed between Hb and serum transferrin (r=-0.552, p<0.001), as well as Hb and serum soluble transferrin receptor (r=-0.552, p<0.001). Remunerated donors had lower Hb (p=0.001) and HCT% (p=0.001) but a higher transferrin receptor (p=0.041) than non-remunerated donors. Conclusion: Regular blood donors had relatively lower erythrocyte parameters but higher serum transferrin and soluble transferrin receptors, indicating a possible reduction in serum iron and iron stores. Moderate negative correlations exist between Hb and both transferrin and soluble transferrin receptors. Again, remunerated donors had lower erythrocyte parameters but higher transferrin and soluble transferrin receptors than non-remunerated donors. Periodic assessment of iron parameters among regular blood donors is recommended. A future longitudinal study to assess the entire iron profile of regular blood donors is recommended. Doi: 10.28991/SciMedJ-2022-04-03-01 Full Text: PDF

Published in SciMedicine Journal

ISSN: 2704-9833 (Online)
Publisher: Ital Publication
Country of publisher: Italy
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Medicine: Public aspects of medicine
Website: https://scimedjournal.org

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