Communications Biology (Jan 2021)
Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice
- Ilaria Bertocchi,
- Ahmed Eltokhi,
- Andrey Rozov,
- Vivan Nguyễn Chi,
- Vidar Jensen,
- Thorsten Bus,
- Verena Pawlak,
- Marta Serafino,
- Hannah Sonntag,
- Boyi Yang,
- Nail Burnashev,
- Shi-Bin Li,
- Horst A. Obenhaus,
- Martin Both,
- Burkhard Niewoehner,
- Frank N. Single,
- Michael Briese,
- Thomas Boerner,
- Peter Gass,
- John Nick P. Rawlins,
- Georg Köhr,
- David M. Bannerman,
- Rolf Sprengel
Affiliations
- Ilaria Bertocchi
- Departments Molecular Neurobiology and Physiology at the Max Planck Institute for Medical Research
- Ahmed Eltokhi
- Research Group of the Max Planck Institute for Medical Research at the Institute for Anatomy and Cell Biology of the Heidelberg University
- Andrey Rozov
- Departments Molecular Neurobiology and Physiology at the Max Planck Institute for Medical Research
- Vivan Nguyễn Chi
- Department of Physiology and Pathophysiology, Heidelberg University
- Vidar Jensen
- Department of Molecular Medicine, Division of Physiology, Institute of Basic Medical Sciences, University of Oslo
- Thorsten Bus
- Departments Molecular Neurobiology and Physiology at the Max Planck Institute for Medical Research
- Verena Pawlak
- Departments Molecular Neurobiology and Physiology at the Max Planck Institute for Medical Research
- Marta Serafino
- Departments Molecular Neurobiology and Physiology at the Max Planck Institute for Medical Research
- Hannah Sonntag
- Departments Molecular Neurobiology and Physiology at the Max Planck Institute for Medical Research
- Boyi Yang
- Departments Molecular Neurobiology and Physiology at the Max Planck Institute for Medical Research
- Nail Burnashev
- Departments Molecular Neurobiology and Physiology at the Max Planck Institute for Medical Research
- Shi-Bin Li
- Departments Molecular Neurobiology and Physiology at the Max Planck Institute for Medical Research
- Horst A. Obenhaus
- Departments Molecular Neurobiology and Physiology at the Max Planck Institute for Medical Research
- Martin Both
- Department of Physiology and Pathophysiology, Heidelberg University
- Burkhard Niewoehner
- Department of Experimental Psychology, University of Oxford, Radcliffe Observatory
- Frank N. Single
- Departments Molecular Neurobiology and Physiology at the Max Planck Institute for Medical Research
- Michael Briese
- Department of Experimental Psychology, University of Oxford, Radcliffe Observatory
- Thomas Boerner
- Department of Experimental Psychology, University of Oxford, Radcliffe Observatory
- Peter Gass
- RG Animal Models in Psychiatry, Animal Models Psychatry, Central Institute of Mental Health (CIMH), Faculty Mannheim, Heidelberg University, J5
- John Nick P. Rawlins
- Department of Experimental Psychology, University of Oxford, Radcliffe Observatory
- Georg Köhr
- Departments Molecular Neurobiology and Physiology at the Max Planck Institute for Medical Research
- David M. Bannerman
- Department of Experimental Psychology, University of Oxford, Radcliffe Observatory
- Rolf Sprengel
- Departments Molecular Neurobiology and Physiology at the Max Planck Institute for Medical Research
- DOI
- https://doi.org/10.1038/s42003-020-01538-4
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 21
Abstract
Ilaria Bertocchi et al. use a mouse model of Grin2a dysfunction to show that activity-independent NMDA receptors are involved in audiogenic seizure generation. Their results suggest a role for NMDA receptors in maintaining an appropriate response to sensory stimuli and a potential mechanism for disease phenotypes in epilepsy patients with GRIN2A mutations.
