Nature Communications (Jan 2020)

Cryo-EM structure of the respiratory syncytial virus RNA polymerase

  • Dongdong Cao,
  • Yunrong Gao,
  • Claire Roesler,
  • Samantha Rice,
  • Paul D’Cunha,
  • Lisa Zhuang,
  • Julia Slack,
  • Mason Domke,
  • Anna Antonova,
  • Sarah Romanelli,
  • Shayon Keating,
  • Gabriela Forero,
  • Puneet Juneja,
  • Bo Liang

DOI
https://doi.org/10.1038/s41467-019-14246-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 9

Abstract

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Respiratory syncytial virus (RSV) is a pathogenic non-segmented negative-sense RNA virus and active RSV polymerase is composed of a 250 kDa large (L) protein and tetrameric phosphoprotein (P). Here, the authors present the 3.67 Å cryo-EM structure of the RSV polymerase (L:P) complex.