Nature Communications (Feb 2021)
Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
- Minh-Phuong Huynh-Le,
- Chun Chieh Fan,
- Roshan Karunamuni,
- Wesley K. Thompson,
- Maria Elena Martinez,
- Rosalind A. Eeles,
- Zsofia Kote-Jarai,
- Kenneth Muir,
- Johanna Schleutker,
- Nora Pashayan,
- Jyotsna Batra,
- Henrik Grönberg,
- David E. Neal,
- Jenny L. Donovan,
- Freddie C. Hamdy,
- Richard M. Martin,
- Sune F. Nielsen,
- Børge G. Nordestgaard,
- Fredrik Wiklund,
- Catherine M. Tangen,
- Graham G. Giles,
- Alicja Wolk,
- Demetrius Albanes,
- Ruth C. Travis,
- William J. Blot,
- Wei Zheng,
- Maureen Sanderson,
- Janet L. Stanford,
- Lorelei A. Mucci,
- Catharine M. L. West,
- Adam S. Kibel,
- Olivier Cussenot,
- Sonja I. Berndt,
- Stella Koutros,
- Karina Dalsgaard Sørensen,
- Cezary Cybulski,
- Eli Marie Grindedal,
- Florence Menegaux,
- Kay-Tee Khaw,
- Jong Y. Park,
- Sue A. Ingles,
- Christiane Maier,
- Robert J. Hamilton,
- Stephen N. Thibodeau,
- Barry S. Rosenstein,
- Yong-Jie Lu,
- Stephen Watya,
- Ana Vega,
- Manolis Kogevinas,
- Kathryn L. Penney,
- Chad Huff,
- Manuel R. Teixeira,
- Luc Multigner,
- Robin J. Leach,
- Lisa Cannon-Albright,
- Hermann Brenner,
- Esther M. John,
- Radka Kaneva,
- Christopher J. Logothetis,
- Susan L. Neuhausen,
- Kim De Ruyck,
- Hardev Pandha,
- Azad Razack,
- Lisa F. Newcomb,
- Jay H. Fowke,
- Marija Gamulin,
- Nawaid Usmani,
- Frank Claessens,
- Manuela Gago-Dominguez,
- Paul A. Townsend,
- William S. Bush,
- Monique J. Roobol,
- Marie-Élise Parent,
- Jennifer J. Hu,
- Ian G. Mills,
- Ole A. Andreassen,
- Anders M. Dale,
- Tyler M. Seibert,
- UKGPCS collaborators,
- APCB (Australian Prostate Cancer BioResource),
- NC-LA PCaP Investigators,
- The IMPACT Study Steering Committee and Collaborators,
- Canary PASS Investigators,
- The Profile Study Steering Committee,
- The PRACTICAL Consortium
Affiliations
- Minh-Phuong Huynh-Le
- Department of Radiation Medicine and Applied Sciences, University of California San Diego
- Chun Chieh Fan
- Center for Multimodal Imaging and Genetics, University of California San Diego
- Roshan Karunamuni
- Department of Radiation Medicine and Applied Sciences, University of California San Diego
- Wesley K. Thompson
- Division of Biostatistics and Halicioğlu Data Science Institute, University of California San Diego
- Maria Elena Martinez
- Moores Cancer Center, Department of Family Medicine and Public Health, University of California San Diego
- Rosalind A. Eeles
- The Institute of Cancer Research
- Zsofia Kote-Jarai
- The Institute of Cancer Research
- Kenneth Muir
- Division of Population Health, Health Services Research and Primary Care, University of Manchester, Oxford Road
- Johanna Schleutker
- Institute of Biomedicine, Kiinamyllynkatu 10, FI-20014 University of Turku
- Nora Pashayan
- University College London, Department of Applied Health Research
- Jyotsna Batra
- Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology
- Henrik Grönberg
- Department of Medical Epidemiology and Biostatistics, Karolinska Institute
- David E. Neal
- Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital
- Jenny L. Donovan
- Population Health Sciences, Bristol Medical School, University of Bristol
- Freddie C. Hamdy
- Nuffield Department of Surgical Sciences, University of Oxford
- Richard M. Martin
- Population Health Sciences, Bristol Medical School, University of Bristol
- Sune F. Nielsen
- Faculty of Health and Medical Sciences, University of Copenhagen
- Børge G. Nordestgaard
- Faculty of Health and Medical Sciences, University of Copenhagen
- Fredrik Wiklund
- Department of Medical Epidemiology and Biostatistics, Karolinska Institute
- Catherine M. Tangen
- SWOG Statistical Center, Fred Hutchinson Cancer Research Center
- Graham G. Giles
- Cancer Epidemiology Division, Cancer Council Victoria
- Alicja Wolk
- Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet
- Demetrius Albanes
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Ruth C. Travis
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford
- William J. Blot
- Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center
- Wei Zheng
- Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center
- Maureen Sanderson
- Department of Family and Community Medicine, Meharry Medical College
- Janet L. Stanford
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Lorelei A. Mucci
- Department of Epidemiology, Harvard T. H. Chan School of Public Health
- Catharine M. L. West
- Division of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Radiotherapy Related Research, The Christie Hospital NHS Foundation Trust
- Adam S. Kibel
- Division of Urologic Surgery, Brigham and Womens Hospital
- Olivier Cussenot
- Sorbonne Universite, GRC n°5, AP-HP, Tenon Hospital, 4 Rue de la Chine
- Sonja I. Berndt
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Stella Koutros
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH
- Karina Dalsgaard Sørensen
- Department of Molecular Medicine, Aarhus University Hospital
- Cezary Cybulski
- International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University
- Eli Marie Grindedal
- Department of Medical Genetics, Oslo University Hospital
- Florence Menegaux
- Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay
- Kay-Tee Khaw
- Clinical Gerontology Unit, University of Cambridge
- Jong Y. Park
- Department of Cancer Epidemiology, Moffitt Cancer Center
- Sue A. Ingles
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center
- Christiane Maier
- Humangenetik Tuebingen
- Robert J. Hamilton
- Department of Surgical Oncology, Princess Margaret Cancer Centre
- Stephen N. Thibodeau
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- Barry S. Rosenstein
- Department of Radiation Oncology and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place
- Yong-Jie Lu
- Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square
- Stephen Watya
- Uro Care
- Ana Vega
- Fundación Pública Galega Medicina Xenómica
- Manolis Kogevinas
- ISGlobal
- Kathryn L. Penney
- Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital/Harvard Medical School
- Chad Huff
- The University of Texas M. D. Anderson Cancer Center
- Manuel R. Teixeira
- Department of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto)
- Luc Multigner
- Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail)—UMR_S 1085
- Robin J. Leach
- Department of Urology, Mays Cancer Center, University of Texas Health Science Center at San Antonio
- Lisa Cannon-Albright
- Division of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine
- Hermann Brenner
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Esther M. John
- Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine
- Radka Kaneva
- Molecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia
- Christopher J. Logothetis
- The University of Texas M. D. Anderson Cancer Center, Department of Genitourinary Medical Oncology
- Susan L. Neuhausen
- Department of Population Sciences, Beckman Research Institute of the City of Hope
- Kim De Ruyck
- Ghent University, Faculty of Medicine and Health Sciences, Basic Medical Sciences
- Hardev Pandha
- The University of Surrey
- Azad Razack
- Department of Surgery, Faculty of Medicine, University of Malaya
- Lisa F. Newcomb
- Division of Public Health Sciences, Fred Hutchinson Cancer Research Center
- Jay H. Fowke
- Department of Medicine and Urologic Surgery, Vanderbilt University Medical Center
- Marija Gamulin
- Department of Oncology, University Hospital Centre Zagreb, University of Zagreb, School of Medicine
- Nawaid Usmani
- Department of Oncology, Cross Cancer Institute, University of Alberta
- Frank Claessens
- Department of Cellular and Molecular Medicine, Molecular Endocrinology Laboratory, KU Leuven
- Manuela Gago-Dominguez
- Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saúde, SERGAS
- Paul A. Townsend
- Division of Cancer Sciences, Manchester Cancer Research Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, University of Manchester
- William S. Bush
- Case Western Reserve University, Department of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology
- Monique J. Roobol
- Department of Clinical Chemistry, Erasmus University Medical Center
- Marie-Élise Parent
- Epidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique
- Jennifer J. Hu
- The University of Miami School of Medicine, Sylvester Comprehensive Cancer Center
- Ian G. Mills
- Nuffield Department of Surgical Sciences, University of Oxford
- Ole A. Andreassen
- NORMENT, KG Jebsen Centre, Oslo University Hospital and University of Oslo
- Anders M. Dale
- Center for Multimodal Imaging and Genetics, University of California San Diego
- Tyler M. Seibert
- Department of Radiation Medicine and Applied Sciences, University of California San Diego
- UKGPCS collaborators
- APCB (Australian Prostate Cancer BioResource)
- NC-LA PCaP Investigators
- The IMPACT Study Steering Committee and Collaborators
- Canary PASS Investigators
- The Profile Study Steering Committee
- The PRACTICAL Consortium
- DOI
- https://doi.org/10.1038/s41467-021-21287-0
- Journal volume & issue
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Vol. 12,
no. 1
pp. 1 – 9
Abstract
A polygenic hazard score (PHS1) improves prostate cancer screening accuracy in European patients. Here, the authors test the performance of a version compatible with OncoArray genotypes (PHS2) in a multi-ethnic dataset and find that it risk-stratifies men for any, aggressive, and fatal prostate cancer.
