Nutrition & Metabolism (Apr 2010)

Circulating omentin concentration increases after weight loss

  • Ricart Wifredo,
  • Gómez-Ambrosi Javier,
  • Ortega Francisco,
  • Catalán Victoria,
  • Moreno-Navarrete José,
  • Frühbeck Gema,
  • Fernández-Real José

DOI
https://doi.org/10.1186/1743-7075-7-27
Journal volume & issue
Vol. 7, no. 1
p. 27

Abstract

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Abstract Background Omentin-1 is a novel adipokine expressed in visceral adipose tissue and negatively associated with insulin resistance and obesity. We aimed to study the effects of weight loss-induced improved insulin sensitivity on circulating omentin concentrations. Methods Circulating omentin-1 (ELISA) concentration in association with metabolic variables was measured in 35 obese subjects (18 men, 17 women) before and after hypocaloric weight loss. Results Baseline circulating omentin-1 concentrations correlated negatively with BMI (r = -0.58, p Conclusion As previously described with adiponectin, circulating omentin-1 concentrations increase after weight loss-induced improvement of insulin sensitivity.