Lochmolins A–G, New Sesquiterpenoids from the Soft Coral <em>Sinularia</em><em> lochmodes</em>

Abstract

Seven new sesquiterpenoids, lochmolins A–G (<strong>1</strong>–<strong>7</strong>), were isolated from a Taiwanese soft coral <em>Sinularia lochmodes</em>. The structures of these metabolites were elucidated by extensive spectroscopic study. Compounds <strong>1</strong>–<strong>4</strong> were found to inhibit the accumulation of the LPS-induced pro-inflammatory COX-2 protein in RAW264.7 macrophage cells.

Keywords

• soft coral
• &lt;em&gt;Sinularia&lt;/em&gt;&lt;em&gt; &lt;/em&gt;&lt;em&gt;lochmodes&lt;/em&gt;
• sesquiterpenes
• aromadendrane
• germacrane