Nature Communications (Aug 2019)

Hydrogen peroxide release by bacteria suppresses inflammasome-dependent innate immunity

  • Saskia F. Erttmann,
  • Nelson O. Gekara

DOI
https://doi.org/10.1038/s41467-019-11169-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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The functions of microbial hydrogen peroxide (H2O2) in host-pathogen interactions are unclear. Here, Erttmann and Gekara show that H2O2 released by Streptococcus pneumoniae inhibits inflammasomes, and thereby contributes to the pathogen’s ability to colonize the host.