Current perspectives in Set7 mediated stem cell differentiation

Nazanin Karimnia; Haloom Rafehi; Natasha K Tuano; Mark Ziemann; Harikrishnan K.N; Jun Okabe; Assam El-Osta

doi:10.3390/ncrna2040014

Non-Coding RNA (Dec 2016)

Current perspectives in Set7 mediated stem cell differentiation

Nazanin Karimnia,
Haloom Rafehi,
Natasha K Tuano,
Mark Ziemann,
Harikrishnan K.N,
Jun Okabe,
Assam El-Osta

Affiliations

Nazanin Karimnia: Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
Haloom Rafehi: Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
Natasha K Tuano: Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
Mark Ziemann: Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
Harikrishnan K.N: Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
Jun Okabe: Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia
Assam El-Osta: Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart and Diabetes Institute, The Alfred Medical Research and Education Precinct, Melbourne, Victoria 3004, Australia

DOI: https://doi.org/10.3390/ncrna2040014
Journal volume & issue: Vol. 2, no. 4
p. 14

Abstract

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Set7 is a key regulatory enzyme involved in the methylation of lysine residues of histone and non-histone proteins. This lysine methyltransferase is induced during stem cell differentiation and regulates lineage specific gene transcription and cell fate. In this article we discuss recent experimental evidence identifying regulatory targets under the control of Set7 as well as emerging evidence of regulation in stem cell differentiation. Furthermore, we discuss the function of non-coding RNAs regulated by Set7 implicated in cell plasticity.

Published in Non-Coding RNA

ISSN: 2311-553X (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Genetics
Website: https://www.mdpi.com/journal/ncrna

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Abstract

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