Journal of Pain Research (Dec 2024)
Functional Brain Changes in Younger Population of Cervical Spondylosis Patients with Chronic Neck Pain
Abstract
Wendi Zhang,1 Zhaohui Chen1,2 1College of Acupuncture and Massage (Rehabilitation Medical College), Anhui University of Chinese Medicine, Hefei, People’s Republic of China; 2Department of Tendon Injury, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, People’s Republic of ChinaCorrespondence: Zhaohui Chen, Email [email protected]: The aim of the research was to observe the variations in brain activity between young cervical spondylosis patients with chronic neck pain (CNP) and healthy volunteers in the resting state and to investigate the central remodeling mechanisms in the patients.Patients and methods: Our study recruited 31 patients with chronic neck pain from cervical spondylosis and 30 healthy volunteers. Eventually, 29 patients (CNP group) and 29 healthy volunteers (HC group) completed the acquisition of clinical data and resting-state functional magnetic resonance (rs BOLD-fMRI) amplitude of low-frequency fluctuations (ALFF) data; in addition, we assessed the relationship between differentially active brain regions and clinical indicators.Results: The CNP group found greater ALFF values in the insula, cingulate gyrus, prefrontal lobe, and other brain regions. The occipital, parietal, and other brain regions had lower ALFF values. In addition, there was a negative connection between the duration of the sickness in the CNP group and the ALFF value of the right superior parietal gyrus (SPG.R). The level of tenderness threshold exhibited a negative correlation with the ALFF value of the left insula (INS.L). In addition, the NPQ score showed a negative association with the ALFF value of the ORBinf.R and a positive correlation with the ALFF value of the CC1.L. Finally, the HADS-A score exhibited a positive correlation with the ALFF value of the right anterior cingulate and paracingulate gyrus (ACG.R).Conclusion: Young patients with chronic neck pain show extensive central remodeling, with altered functional activity in pain-emotion brain areas (such as the cingulate gyrus and insula), pain-cognition brain areas (such as the prefrontal lobe), and other special sensory brain areas (such as the parietal and occipital lobes). These changes are linked to clinical tenderness, functional disability, and negative emotion indicators.Keywords: cervical spondylosis, chronic neck pain, central remodeling, resting-state functional magnetic resonance, young population
