Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1

Yu-Xiong Feng; Dexter X. Jin; Ethan S. Sokol; Ferenc Reinhardt; Daniel H. Miller; Piyush B. Gupta

doi:10.1038/s41467-017-01052-y

Nature Communications (Oct 2017)

Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1

Yu-Xiong Feng,
Dexter X. Jin,
Ethan S. Sokol,
Ferenc Reinhardt,
Daniel H. Miller,
Piyush B. Gupta

Affiliations

Yu-Xiong Feng: Whitehead Institute for Biomedical Research
Dexter X. Jin: Whitehead Institute for Biomedical Research
Ethan S. Sokol: Whitehead Institute for Biomedical Research
Ferenc Reinhardt: Whitehead Institute for Biomedical Research
Daniel H. Miller: Whitehead Institute for Biomedical Research
Piyush B. Gupta: Whitehead Institute for Biomedical Research

DOI: https://doi.org/10.1038/s41467-017-01052-y
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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PERK stress signaling is an important driver of cancer invasion and metastasis, but chemical inhibitors of PERK cause side effects. Here, the authors find that CREB3L1 is required for PERK's pro-metastatic function in breast cancer, and its inhibition suppresses cancer invasion and metastasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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