Nature Communications (Jul 2021)
Retinoblastoma from human stem cell-derived retinal organoids
- Jackie L. Norrie,
- Anjana Nityanandam,
- Karen Lai,
- Xiang Chen,
- Matthew Wilson,
- Elizabeth Stewart,
- Lyra Griffiths,
- Hongjian Jin,
- Gang Wu,
- Brent Orr,
- Quynh Tran,
- Sariah Allen,
- Colleen Reilly,
- Xin Zhou,
- Jiakun Zhang,
- Kyle Newman,
- Dianna Johnson,
- Rachel Brennan,
- Michael A. Dyer
Affiliations
- Jackie L. Norrie
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- Anjana Nityanandam
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- Karen Lai
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- Xiang Chen
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Matthew Wilson
- Department of Ophthalmology, University of Tennessee Health Science Center
- Elizabeth Stewart
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- Lyra Griffiths
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- Hongjian Jin
- Center for Applied Bioinformatics, St. Jude Children’s Research Hospital
- Gang Wu
- Center for Applied Bioinformatics, St. Jude Children’s Research Hospital
- Brent Orr
- Department of Pathology, St. Jude Children’s Research Hospital
- Quynh Tran
- Department of Pathology, St. Jude Children’s Research Hospital
- Sariah Allen
- Department of Pathology, St. Jude Children’s Research Hospital
- Colleen Reilly
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Xin Zhou
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Jiakun Zhang
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- Kyle Newman
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- Dianna Johnson
- Department of Ophthalmology, University of Tennessee Health Science Center
- Rachel Brennan
- Department of Oncology, St. Jude Children’s Research Hospital
- Michael A. Dyer
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- DOI
- https://doi.org/10.1038/s41467-021-24781-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Retinoblastoma is a heritable pediatric cancer driven by mutations in RB1. Here, the authors demonstrate the first patient derived model of retinoblastoma using iPSCs from patients with germline mutations in RB1.
