Современная онкология (Aug 2021)

Prostate cancer

  • Andrei D. Kaprin,
  • Boris Ia. Alekseev,
  • Vsevolod B. Matveev,
  • Dmitrii Iu. Pushkar’,
  • Aleksandr V. Govorov,
  • Nina A. Gorban’,
  • Andrei A. Kirichek,
  • Vitalii A. Biriukov,
  • Mariia I. Volkova,
  • Igor A. Gulidov,
  • Iuliia V. Gumenetskaia,
  • Valerii V. Krylov,
  • Oleg B. Kariakin,
  • Aleksei A. Krasheninnikov,
  • Iurii S. Mardynskii,
  • Kirill M. Niushko,
  • Tatiana I. Zakharova,
  • Andrei A. Kostin,
  • Evgenii V. Khmelevskii,
  • Aleksandr A. Fedenko,
  • Larisa V. Bolotina,
  • Natalia A. Falaleeva,
  • Elena V. Filonenko,
  • Aleksei A. Nevol’skikh,
  • Sergei A. Ivanov,
  • Zhanna V. Khailova,
  • Tigran G. Gevorkian

DOI
https://doi.org/10.26442/18151434.2021.2.200959
Journal volume & issue
Vol. 23, no. 2
pp. 211 – 247

Abstract

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Prostate cancer (RPP) is a malignant neoplasm that arises from the epithelium of the prostate gland gland (PJ). Thethiology and pathogenesis of this disease remain poorly studied. Many studies are aimed at studying diet, food, hormonal impact, as well as infections in the etiology of the RLPG. The prevalence of RPL depends on ethnic and geographical features. The highest incidence of African Americans living in the United States (60% higher than that of white Americans), the least high - in the Chinese living in China [1]. In addition to racial features, the risk factors of the RPG are considering the genetic predisposition, the age of men and nutritional features. The probability of developing a PJ tumor in a man who has one of the closest relatives of the first degree of kinship (father or brother) sick of the RLPG, is 1.8 times higher than in the population. If two relatives were sick or more (father and brother or both brothers), the risk of RPG increases in 5.51 and 7.71 times, respectively [2, 3]. African Americans have an increased risk of identifying RPG, as well as a greater probability of detecting aggressive RPG [4]. Also, the risk of RLPG is rising in men who use a large amount of animal fats [5].

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