Active conformation of the p97-p47 unfoldase complex

Yang Xu; Han Han; Ian Cooney; Yuxuan Guo; Noah G. Moran; Nathan R. Zuniga; John C. Price; Christopher P. Hill; Peter S. Shen

doi:10.1038/s41467-022-30318-3

Nature Communications (May 2022)

Active conformation of the p97-p47 unfoldase complex

Yang Xu,
Han Han,
Ian Cooney,
Yuxuan Guo,
Noah G. Moran,
Nathan R. Zuniga,
John C. Price,
Christopher P. Hill,
Peter S. Shen

Affiliations

Yang Xu: Department of Biochemistry, 15 N. Medical Drive East, University of Utah
Han Han: Department of Biochemistry, 15 N. Medical Drive East, University of Utah
Ian Cooney: Department of Biochemistry, 15 N. Medical Drive East, University of Utah
Yuxuan Guo: Department of Biochemistry, 15 N. Medical Drive East, University of Utah
Noah G. Moran: Department of Chemistry and Biochemistry, C100 BNSN, Brigham Young University
Nathan R. Zuniga: Department of Chemistry and Biochemistry, C100 BNSN, Brigham Young University
John C. Price: Department of Chemistry and Biochemistry, C100 BNSN, Brigham Young University
Christopher P. Hill: Department of Biochemistry, 15 N. Medical Drive East, University of Utah
Peter S. Shen: Department of Biochemistry, 15 N. Medical Drive East, University of Utah

DOI: https://doi.org/10.1038/s41467-022-30318-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 8

Abstract

Read online

The p97 unfoldase is an essential and abundant enzyme that segregates its substrates from macromolecular complexes and organelle membranes. Here, authors determined the structure of human p97 in the act of unfolding an authentic substrate.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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