Frontiers in Pharmacology (Apr 2022)
Application of Quercetin in the Treatment of Gastrointestinal Cancers
- Seyed Mohammad Ali Mirazimi,
- Fatemeh Dashti,
- Mohammad Tobeiha,
- Mohammad Tobeiha,
- Ali Shahini,
- Raha Jafari,
- Mehrad Khoddami,
- Amir Hossein Sheida,
- Amir Hossein Sheida,
- Parastoo EsnaAshari,
- Parastoo EsnaAshari,
- Amir Hossein Aflatoonian,
- Amir Hossein Aflatoonian,
- Fateme Elikaii,
- Fateme Elikaii,
- Melika Sadat Zakeri,
- Melika Sadat Zakeri,
- Michael R Hamblin,
- Mohammad Aghajani,
- Minoodokht Bavarsadkarimi,
- Hamed Mirzaei
Affiliations
- Seyed Mohammad Ali Mirazimi
- School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
- Fatemeh Dashti
- School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
- Mohammad Tobeiha
- School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
- Mohammad Tobeiha
- Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
- Ali Shahini
- Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
- Raha Jafari
- Department of Medicine, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran
- Mehrad Khoddami
- Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
- Amir Hossein Sheida
- School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
- Amir Hossein Sheida
- Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
- Parastoo EsnaAshari
- School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
- Parastoo EsnaAshari
- Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
- Amir Hossein Aflatoonian
- School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
- Amir Hossein Aflatoonian
- Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
- Fateme Elikaii
- School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
- Fateme Elikaii
- Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
- Melika Sadat Zakeri
- School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
- Melika Sadat Zakeri
- Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
- Michael R Hamblin
- Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, South Africa
- Mohammad Aghajani
- Infectious Disease Research Center, School of Nursing and Midwifery, Kashan University of Medical Sciences, Kashan, Iran
- Minoodokht Bavarsadkarimi
- Clinical Research Development Center, Mahdiyeh Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
- Hamed Mirzaei
- Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
- DOI
- https://doi.org/10.3389/fphar.2022.860209
- Journal volume & issue
-
Vol. 13
Abstract
Many cellular signaling pathways contribute to the regulation of cell proliferation, division, motility, and apoptosis. Deregulation of these pathways contributes to tumor cell initiation and tumor progression. Lately, significant attention has been focused on the use of natural products as a promising strategy in cancer treatment. Quercetin is a natural flavonol compound widely present in commonly consumed foods. Quercetin has shown significant inhibitory effects on tumor progression via various mechanisms of action. These include stimulating cell cycle arrest or/and apoptosis as well as its antioxidant properties. Herein, we summarize the therapeutic effects of quercetin in gastrointestinal cancers (pancreatic, gastric, colorectal, esophageal, hepatocellular, and oral).
Keywords
