Molecules
(Sep 2015)
Asymmetric Synthesis of 1,3-Oxazolidine Derivatives with Multi-Component Reaction and Research of Kinetic Resolution
Xiao-Wei Hong,
Yu-Qiang Zhou,
Cui-Bing Bai,
Nai-Xing Wang,
Yalan Xing,
Wei Zhang,
Yan-Jing Wang,
Xing-Wang Lan,
Yu Xie,
Yi-He Li
Affiliations
Xiao-Wei Hong
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, China
Yu-Qiang Zhou
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, China
Cui-Bing Bai
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, China
Nai-Xing Wang
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, China
Yalan Xing
Department of Chemistry, William Paterson University of New Jersey, 300 Pompton Road, Wayne, NJ 07470, USA
Wei Zhang
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, China
Yan-Jing Wang
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, China
Xing-Wang Lan
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, China
Yu Xie
College of Environment and Chemical Engineering, Nanchang Hangkong University, Nanchang 330063, China
Yi-He Li
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, China
DOI
https://doi.org/10.3390/molecules200917208
Journal volume & issue
Vol. 20,
no. 9
Abstract
Read online
An efficient multi-component reaction to synthesize multi-substituted 1,3-oxazolidine compounds of high optical purity was described. All the products were well-characterized and the absolute configuration of one chiral center was determined. The plausible mechanism was proposed and a kinetic resolution of epoxides process was confirmed.
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