The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits

Aldons J. Lusis; Marcus M. Seldin; Hooman Allayee; Brian J. Bennett; Mete Civelek; Richard C. Davis; Eleazar Eskin; Charles R. Farber; Simon Hui; Margarete Mehrabian; Frode Norheim; Calvin Pan; Brian Parks; Christoph D. Rau; Desmond J. Smith; Thomas Vallim; Yibin Wang; Jessica Wang

Journal of Lipid Research (Jun 2016)

The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits

Aldons J. Lusis,
Marcus M. Seldin,
Hooman Allayee,
Brian J. Bennett,
Mete Civelek,
Richard C. Davis,
Eleazar Eskin,
Charles R. Farber,
Simon Hui,
Margarete Mehrabian,
Frode Norheim,
Calvin Pan,
Brian Parks,
Christoph D. Rau,
Desmond J. Smith,
Thomas Vallim,
Yibin Wang,
Jessica Wang

Affiliations

Aldons J. Lusis: Departments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA; Microbiology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA; Human Genetics, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA; To whom correspondence should be addressed
Marcus M. Seldin: Departments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA
Hooman Allayee: Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA
Brian J. Bennett: Department of Genetics, University of North Carolina, Chapel Hill, NC
Mete Civelek: Departments of Biomedical Engineering University of Virginia, Charlottesville, VA
Richard C. Davis: Departments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA
Eleazar Eskin: Departments of Computer Science, University of California-Los Angeles, Los Angeles, CA
Charles R. Farber: Public Health Sciences, University of Virginia, Charlottesville, VA
Simon Hui: Departments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA
Margarete Mehrabian: Departments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA
Frode Norheim: Departments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA
Calvin Pan: Human Genetics, University of California-Los Angeles, Los Angeles, CA
Brian Parks: Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI
Christoph D. Rau: Anesthesiology, University of California-Los Angeles, Los Angeles, CA
Desmond J. Smith: Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA
Thomas Vallim: Departments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA
Yibin Wang: Anesthesiology, University of California-Los Angeles, Los Angeles, CA
Jessica Wang: Departments of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA

Journal volume & issue: Vol. 57, no. 6
pp. 925 – 942

Abstract

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The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized inbred strains of mice that can be used to analyze the genetic and environmental factors underlying complex traits. While not nearly as powerful for mapping genetic loci contributing to the traits as human genome-wide association studies, it has some important advantages. First, environmental factors can be controlled. Second, relevant tissues are accessible for global molecular phenotyping. Finally, because inbred strains are renewable, results from separate studies can be integrated. Thus far, the HMDP has been studied for traits relevant to obesity, diabetes, atherosclerosis, osteoporosis, heart failure, immune regulation, fatty liver disease, and host-gut microbiota interactions. High-throughput technologies have been used to examine the genomes, epigenomes, transcriptomes, proteomes, metabolomes, and microbiomes of the mice under various environmental conditions. All of the published data are available and can be readily used to formulate hypotheses about genes, pathways and interactions.

Published in Journal of Lipid Research

ISSN: 0022-2275 (Print); 1539-7262 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.journals.elsevier.com/journal-of-lipid-research

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Abstract

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