Complex DNA knots detected with a nanopore sensor

Rajesh Kumar Sharma; Ishita Agrawal; Liang Dai; Patrick S. Doyle; Slaven Garaj

doi:10.1038/s41467-019-12358-4

Nature Communications (Oct 2019)

Complex DNA knots detected with a nanopore sensor

Rajesh Kumar Sharma,
Ishita Agrawal,
Liang Dai,
Patrick S. Doyle,
Slaven Garaj

Affiliations

Rajesh Kumar Sharma: Department of Biomedical Engineering, National University of Singapore
Ishita Agrawal: Department of Biomedical Engineering, National University of Singapore
Liang Dai: Department of Physics, City University of Hong Kong
Patrick S. Doyle: Singapore-MIT Alliance for Research and Technology Centre
Slaven Garaj: Department of Biomedical Engineering, National University of Singapore

DOI: https://doi.org/10.1038/s41467-019-12358-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

Read online

Nanopore microscopy is capable of detecting knots in DNA polymers, a common structural feature. Here the authors show nanopore sensors can map the equilibrium structure of these knots between tight and loose states.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal