Nature Communications (May 2017)

Signalome-wide assessment of host cell response to hepatitis C virus

  • Gholamreza Haqshenas,
  • Jianmin Wu,
  • Kaylene J. Simpson,
  • Roger J. Daly,
  • Hans J. Netter,
  • Thomas F. Baumert,
  • Christian Doerig

DOI
https://doi.org/10.1038/ncomms15158
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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Development of antiviral strategies depends on an understanding of virus–host interactions. Here, using HCV, Haqshenaset al. show that antibody microarray combined with a targeted siRNA screen can be a powerful tool to identify cellular signalling pathways that are important for virus replication.